Repetitive high-power discharge operation of a micro-laser triggered gas switch.

A low-energy, diode-pumped, solid-state passively Q-switched laser operating at a wavelength of 1535 nm has been demonstrated to trigger gas switches. This technology has the potential to bring significant improvements to the operation and reliability of compact pulsed power drivers. Compact pulsed power drivers are often required to operate for hundreds to thousands of shots without maintenance; thus, the reliable operation of the laser triggered switch is significant for the adoption of this technology.

A parametric SPICE model for the simulation of spark gap switches.

The use of SPICE-based software for the simulation of pulsed power systems-even large complex systems-has become commonplace in the pulsed power community. This is in contrast to earlier work in the field that relied on specially developed simulation codes such as Sandia's Screamer or the Navy Research Lab's Bertha, which natively incorporated models for common pulsed power components such as spark gap switches. Unlike these programs, SPICE programs provide a simple and familiar user interface and wide availability.

Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features.

SOX5 encodes a transcription factor involved in the regulation of chondrogenesis and the development of the nervous system. Despite its important developmental roles, SOX5 disruption has yet to be associated with human disease. We report one individual with a reciprocal translocation breakpoint within SOX5, eight individuals with intragenic SOX5 deletions (four are apparently de novo and one inherited from an affected parent), and seven individuals with larger 12p12 deletions encompassing SOX5.

Adults with Rubinstein-Taybi syndrome.

Information in the medical literature regarding adults with genetic syndromes is limited, making the care of these patients challenging. We conducted a questionnaire study of adults with Rubinstein-Taybi syndrome that addressed medical problems, education, independence, and behavior. The most common medical problems included short stature, obesity, visual difficulties, keloids, eating problems, spine curvature, and joint problems.