Comparative diltiazem plasma clearance in normotensive and hypertensive rats.

Diltiazem plasma clearance was studied in normotensive (NR) and spontaneous hypertensive rats (SHR), either following intravenous bolus administration of 3 mg/kg (CLiv), or after 25 min of intravenous infusion (CL25) at different dose levels (1, 2, 4, and 8 mg/kg/30 min in NR; 0.5, 1, 2, and 4 mg/kg/30 min in SHR). The diltiazem pharmacokinetic profile fit a two-compartment open model better, both in NR and SHR.

Kinetics of pharmacological effect of diltiazem in spontaneous hypertensive rats.

The kinetics of intravenous (i.v.) infusion of diltiazem was studied in spontaneous hypertensive rats (SHR) at three dose levels (1, 2 and 4 mg/kg/30 min).