Publications by authors named "J Caleb Snider"
Following spinal cord injury (SCI), there is a short-lived recovery phase that ultimately plateaus. Understanding changes within the spinal cord over time may facilitate targeted approaches to prevent and/or reverse this plateau and allow for continued recovery. Untargeted metabolomics revealed distinct metabolic profiles within the injured cord during recovery (7 days postinjury [DPI]) and plateau (21 DPI) periods in a mouse model of severe contusion SCI.
View Article and Find Full Text PDFElucidation of protein-protein interactions (PPIs) represents one of the most important methods in biomedical research. Recently, PPIs have started to be exploited for drug discovery purposes and have thus attracted much attention from both the academic and pharmaceutical sectors. We previously developed a sensitive method, Split Intein-Mediated Protein Ligation (SIMPL), for detecting binary PPIs via irreversible splicing of the interacting proteins being investigated.
View Article and Find Full Text PDFPurpose: BRAF and MEK inhibitors are standard treatments in histiocytic disorders, such as Erdheim-Chester disease (ECD). Some patients lack MAPK-pathway alterations, making these treatments less effective.
Methods: We describe three patients with histiocytic disorders who have novel non-MAPK pathway alterations.
Article Synopsis
- - The study explores the effectiveness and safety of combining checkpoint inhibitor immunotherapy with radiation therapy for high-risk soft tissue sarcomas in a phase I/II trial, focusing on patients with tumors larger than 5 cm.
- - Out of 23 patients enrolled, only 18 completed the full treatment protocol, with significant adverse effects observed in the majority, but 44.4% showed an excellent histological response post-treatment.
- - The trial, known as the NEXIS trial, included treatments with anti-PD-L1 and anti-CTLA-4 therapies followed by surgery and was registered on ClinicalTrials.gov to ensure oversight and transparency.
Purpose: Since the inaugural workshop "Understanding High-Dose, Ultra-High Dose Rate and Spatially Fractionated Radiotherapy." hosted by the NCI and sponsored by the Radiosurgery Society (RSS), growing collaborations and investigations have ensued among experts, practitioners, and researchers. The RSS GRID, Lattice, Microbeam & FLASH (GLMF) Working Groups were formed as a framework for these efforts and have focused on advancing the understanding of the biology, technical/physical parameters, trial design, and clinical practice of these new radiation therapy modalities.
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