DNA methylation clocks provide information not only about chronological but also biological age, offering a high-resolution and precise understanding of age-related pathology and physiology. Attempts based on transcriptomic and epigenetic approaches arise as integrative biomarkers linking the quantification of stress responses with specific fitness traits and may help identify biological age markers, which are also considered welfare indicators. In gilthead sea bream, targeted gene expression and DNA methylation analyses in white skeletal muscle proved as a reliable marker of age-mediated changes in energy metabolism.
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July 2024
Fish were kept for six weeks at three different initial stocking densities and water O concentrations (low-LD, 8.5 kg/m and 95-70% O saturation; medium-MD, 17 kg/m and 55-75% O saturation; high-HD, 25 kg/m and 60-45% O saturation), with water temperature increasing from 19 °C to 26-27 °C. The improvement in growth performance with the decrease in stocking density was related to changes in skin and intestinal mucosal microbiomes.
View Article and Find Full Text PDFThe Sirtuin (SIRT1-7) family comprises seven evolutionary-conserved enzymes that couple cellular NAD availability with health, nutrition and welfare status in vertebrates. This study re-annotated the sirt3/5 branch in the gilthead sea bream, revealing three paralogues of (//) and two of (/) in this Perciform fish. The phylogeny and synteny analyses unveiled that the Sirt3.
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