Tolerance of skin allografts incompatible at the entire H-2 complex induced in adult mice by the post-transplant treatment.

Permanent tolerance of the entire H-2 complex incompatible B10 skin allografts was induced in adult B10.A mice by post-transplant treatment. Recipient mice were treated with heterologous antithymocyte serum (ATS) and specific tissue extracts or monoclonal antibodies anti-Thy-1.

Prolongation of skin allograft survival in ATS-treated mice by post-transplant injections of species antigenic extracts.

B10.A male mice were grafted with H-2-incompatible murine B10.A(2R) skin allografts and treated with antithymocyte serum on days 2, 4, and 7 after transplantation.

Adoptive transfers of transplantation tolerance in genetically different strain combinations of mice.

Neonatal transplantation tolerance was induced in strain combinations of mice involving differences in the H-2D or H-2K regions, in the K or D ends of H-2, or in the central I region of the H-2 complex. Attempts were made to transfer the tolerance adoptively by suppressor cells to syngeneic non-immunosuppressed recipients. Adoptive transfer of tolerance was successful only in the combination with H-2D region disparity, and significant but short-lasting prolongation of skin allograft survival time was also obtained in the combination disparate at the D end of H-2.

Mechanisms of tolerance of the Ia antigen disparate skin allografts.

Transplantation tolerance was induced in A.TL mice to donors having disparity in the Ia antigens and identity at the H-2K, H-2D and non-H-2 antigens. After neonatal injection of 12 X 10(6) semiallogeneic lymphoid cells, permanent survival of A.