A novel technique for heart-thymus en bloc transplantation in nonhuman primates.

The thymus is a rich source of regulatory T cells and plays a role in self-tolerance. Therefore, transplantation of a vascularized donor thymus may facilitate the induction of tolerance in recipients of a cotransplanted heart allograft. To investigate this hypothesis, we developed a new technique to procure the heart and thymus en bloc from juvenile donors and transplant the composite allograft into thymectomized recipients.

Cognition in elite soccer players: a general model.

This paper presents a general model of the cognitive processes involved in each play situation of soccer at the elite level. Theoretically the model draws on general frameworks from cognitive psychology and neuroscience, in particular the affordance competition hypothesis and the reward prediction error theory. The model includes three functional stages: situational assessment, action selection and execution, and outcome assessment.

A Principled Approach to Adjust for Unmeasured Time-Stable Confounding of Supervised Treatment.

We propose a novel method to adjust for unmeasured time-stable confounding when the time between consecutive treatment administrations is fixed. We achieve this by focusing on a new-user cohort. Furthermore, we envisage that all time-stable confounding goes through the potential time on treatment as dictated by the disease condition at the initiation of treatment.

Validation and clinical impact of motion-free PET imaging using data-driven respiratory gating and elastic PET-CT registration.

Purpose: Clinical whole-body (WB) PET images can be compensated for respiratory motion using data-driven gating (DDG). However, PET DDG images may still exhibit motion artefacts at the diaphragm if the CT is acquired in a different respiratory phase than the PET image. This study evaluates the combined use of PET DDG and a deep-learning model (AIR-PETCT) for elastic registration of CT (WarpCT) to the non attenuation- and non scatter-corrected PET image (PET NAC), enabling improved PET reconstruction.