Publications by authors named "J C van den Noort"
Imiquimod (IMQ; brand name Aldara®) is a registered topical agent that has been proven to induce local inflammation via the Toll-like receptor (TLR)7 pathway. The purpose of this study was to characterize TLR7-mediated inflammation following 7 days (168 h) of topical IMQ exposure in healthy volunteers, and to compare the effects of short exposure (48 h-72 h) with prolonged exposure (120 h-168 h). IMQ (100mg) was applied under occlusion to 5 different tape-stripped treatment sites on the back of 10 healthy participants for a maximum of 7 consecutive days.
View Article and Find Full Text PDFAt the core of molecular biology lies the intricate interplay between sequence, structure, and function. Single-molecule techniques provide in-depth dynamic insights into structure and function, but laborious assays impede functional screening of large sequence libraries. We introduce high-throughput Single-molecule Parallel Analysis for Rapid eXploration of Sequence space (SPARXS), integrating single-molecule fluorescence with next-generation sequencing.
View Article and Find Full Text PDFWhole-heart 4D-flow MRI is a valuable tool for advanced visualization and quantification of blood flow in cardiovascular imaging. Despite advantages over 2D-phase-contrast flow, clinical implementation remains only partially exploited due to many hurdles in all steps, from image acquisition, reconstruction, postprocessing and analysis, clinical embedment, reporting, legislation, and regulation to data storage. The intent of this manuscript was 1) to evaluate the extent of clinical implementation of whole-heart 4D-flow MRI, 2) to identify hurdles hampering clinical implementation, and 3) to reach consensus on requirements for clinical implementation of whole-heart 4D-flow MRI.
View Article and Find Full Text PDFArticle Synopsis
- Genomes are essential for life as they hold the genetic instructions, requiring a balance between tight packing and gene accessibility for organism functionality.
- Recent advancements in single-molecule force spectroscopy, especially using magnetic tweezers, have revolutionized the study of DNA organization, enabling precise measurements and manipulations at the nanoscale.
- This text outlines the methodology for preparing DNA for experimentation, including how to create flow cells and analyze the behavior of DNA under physical forces to extract data about nucleoprotein interactions.
Article Synopsis
- - This study compares two types of coordinate systems used to analyze foot movement: marker-based coordinate systems (MCSs) and bone morphology-based coordinate systems (BCSs), focusing on how they relate to the foot's underlying anatomy.
- - The research involved placing markers on the feet of fifteen healthy adults and using CT scans to examine the orientation differences between MCSs and BCSs, measured in angles like helical and 3D Euler.
- - Findings revealed that MCSs were often misaligned with BCSs, particularly showing different orientations in the hindfoot and forefoot, and only certain models (RFM and AFM) effectively captured variability in foot bone poses across individuals.