Publications by authors named "J C van Hal-Van Gestel"
Article Synopsis
- Understanding the function of bacterial genes is challenging, but double-mutant genetic interaction analysis helps identify how genes work together by linking unknown genes to established pathways.
- The research introduces double-CRISPRi as a method to measure genetic interactions on a large scale, even for essential genes, leading to the discovery of over 1000 known and new interactions.
- Findings highlight the unique roles of similar genes and uncover new genes tied to cell division, showcasing double-CRISPRi's potential for exploring bacterial gene networks in future studies.
Soils host complex multi-trophic communities with diverse, mostly microbial, predator and prey species, including numerous bacterivorous protists and bacterial prey. The molecular mechanisms underlying microbial predator-prey interactions have thus far mainly been explored using reductionist methods, outside the soil environment and independent from the broader life history strategies that microbes display in soils. In this Comment, we advocate for an integrative research approach, combining molecular systems biology and microbial ecology, to investigate how predator-prey interactions shape microbial life history strategies and thereby population dynamics in natural soil communities.
View Article and Find Full Text PDFBacteria commonly adhere to surfaces where they compete for both space and resources. Despite the importance of surface growth, it remains largely elusive how bacteria evolve on surfaces. We previously performed an evolution experiment where we evolved distinct Bacilli populations under a selective regime that favored colony spreading.
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- Understanding kidney repair after acute kidney injury (AKI) involves studying how certain kidney cells respond, particularly the differences between adaptive (healing) and maladaptive (problematic) responses.
- Researchers used advanced techniques to trace cell lineage and analyze gene expression in kidney cells post-AKI, finding that a large number of kidney cells enter the cell cycle in response to injury.
- They discovered that some damaged proximal tubule cells (PTCs) can persist for months after AKI, indicating long-term consequences, and identified distinct regulatory features that drive both healing and ongoing injury responses in these cells.
Background: Tacrolimus (TAC) combined with mycophenolate mofetil (MMF) is the immunosuppressive regimen in the majority of solid organ transplant recipients. Gastrointestinal complaints are frequent, which is considered predominantly a side effect of MMF. However, systematic research in this field is lacking.
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