A photoswitchable [2]catenane receptor.

A [2]catenane-based receptor functionalized with stiff-stilbene can be reversibly switched with 340/385 nm light between its - and -isomers, which leads to a considerable change in chloride binding affinity. Photoisomerization in the presence of chloride allows for on demand guest uptake and release.

Outcomes and Complications of Chait Trapdoor Cecostomy in Pediatric Patients with Therapy-Resistant Constipation and Fecal Incontinence: A 14-Year Retrospective Study.

Aim of the study To assess the incidence and types of complications and patient-reported outcomes in pediatric patients with therapy-resistant constipation or fecal incontinence (FI) without constipation who underwent Chait TrapdoorTM cecostomy (CTC). The findings contribute to the discussion on selecting the optimal antegrade continence (ACE) procedure for this population. Materials and Methods A retrospective review was conducted on all pediatric patients with therapy-resistant constipation or FI without constipation who underwent a CTC procedure at our tertiary referral center between 2009 and 2023.

A unified neurocomputational model of prospective and retrospective timing.

Time is a central dimension against which perception, action, and cognition play out. From anticipating when future events will happen to recalling how long ago previous events occurred, humans and animals are exquisitely sensitive to temporal structure. Empirical evidence seems to suggest that estimating time prospectively (i.

Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability.

Colorectal cancer (CRC) is stratified into four consensus molecular subtypes (CMS1-4). CMS3 represents the metabolic subtype, but its wiring remains largely undefined. To identify the underlying tumorigenesis of CMS3, organoids derived from 16 genetically engineered mouse models are analyzed.

'Let it stay in the heart': cultural and gendered experiences of distress among Syrian refugees in Jordan.

Objective: This study explored cultural and gendered experiences of distress among Syrian refugees in Jordan to inform mental health and psychosocial support services with the population. We sought to understand perceived causes of distress, salient expressions used to describe distress, and ways of coping.

Methods: Eight focus group discussions (FGDs) were conducted with adult Syrian refugees (four male, four female).