Publications by authors named "J C Wiggins"
Background: Women with ovarian cancer (OC) and a pathogenic variant in the BRCA1 or BRCA2 genes are at increased risk of developing breast cancer (BC). Evidence for long term outcomes in these patients who undergo bilateral risk reduction mastectomy (RRM) after ovarian cancer is sparse. The aim of this study was to analyse the long-term breast cancer-related outcomes of patients who have been diagnosed with ovarian cancer and found to have BRCA1 or 2 pathogenic variants.
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- * Researchers used light to activate specially designed nanoparticles that can increase the permeability of the BSCB, allowing normally restricted peptides to enter the spinal cord without harming the surrounding cells or affecting movement.
- * The method effectively delivered the peptide bombesin into the spinal cord, leading to a quick rise in itching behavior in mice, showcasing potential for non-invasive therapies targeting spinal cord conditions.
Elevated youth irritability is characterized by increased proneness to frustration relative to peers when rewards are blocked, and is a transdiagnostic symptom that predicts multiple forms of psychopathology and poorer socioeconomic outcomes in adulthood. Although mechanistic models propose that irritability is the result of aberrant reward-related brain function, youth irritability as it relates to multiple components of reward processes, including reward anticipation, gain, and loss, has yet to be examined in large, population-based samples. Data from the Adolescent Brain and Cognitive Development (ABCD) baseline sample (N = 5923) was used to examine associations between youth irritability (measured by parent-report) and reward-related brain activation and connectivity in a large, preadolescent sample.
View Article and Find Full Text PDFLectins are a class of carbohydrate-binding proteins that may have antiviral activity by binding to the glycans on the virion surface to interfere with viral entry. We have identified a novel lectin (named Shictin) from Shiitake mushroom ()-derived vesicle-like nanoparticles (VLNs, or exosomes) that exhibits strong activity against the SARS-CoV-2 Omicron variant with an IC value of 87 nM. Shictin contains 298 amino acids and consists of two unique domains (N-terminal and C-terminal domain).
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- * Four distinct profiles emerged based on socioeconomic status and family risk factors: High-SES High-Protective, High-SES Low-Protective, Low-SES High-Family-Risk, and Low-SES High-Protective, showing that individual circumstances influence mental health outcomes.
- * The research found that initial profile membership was linked to current and future psychopathology, and changes in profile status over time also predicted mental health issues, highlighting the complexity of adolescent development and the importance of targeted interventions.