Publications by authors named "J C Weinreb"
The US Department of Veterans Affairs (VA) and the US Department of Defense (DoD) approved a joint clinical practice guideline for the management of type 2 diabetes. This was the product of a multidisciplinary guideline development committee composed of clinicians from both the VA and the DoD and was overseen by the VA/DoD Evidence Based Practice Work Group. The development process conformed to the standards for trustworthy guidelines as established by the National Academy of Medicine.
View Article and Find Full Text PDFWe previously demonstrated that RNA helicase DDX3X (DDX3) can be a therapeutic target in Ewing sarcoma (EWS), but its role in EWS biology remains unclear. The present work demonstrates that DDX3 plays a unique role in DNA damage repair (DDR). We show that DDX3 interacts with several proteins involved in homologous recombination, including RAD51, RECQL1, RPA32, and XRCC2.
View Article and Find Full Text PDFPurpose: Treatment guidelines for gender-affirming hormone therapy with estrogen (GAHT-E) recommend specific dosing regimens based on limited data. Well-controlled efficacy trials are essential to tailoring treatment to patient goals as the guidelines recommend. The goal of this study was to take a foundational step toward designing community-centered effectiveness trials for gender-diverse individuals seeking GAHT-E.
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- The study focuses on identifying risk factors for blood transfusions in patients undergoing single-level anterior lumbar interbody fusion (ALIF), a common spinal surgery that often requires transfusions due to complications like infections and adverse reactions.
- Researchers analyzed data from 4,792 patients who underwent this surgery between 2005 and 2018, using various statistical tests to pinpoint factors that increase the likelihood of needing a transfusion within 72 hours after the procedure.
- Key risk factors identified include age over 60, previous transfusions, longer surgical times, higher ASA classifications, and specific preoperative hematocrit levels, which can help in better managing patients before surgery.
Magnetic resonance imaging (MRI) has become integral to diagnosing and managing patients with suspected or confirmed prostate cancer. However, the benefits of utilizing MRI can be hindered by quality issues during imaging acquisition, interpretation, and reporting. As the utilization of prostate MRI continues to increase in clinical practice, the variability in MRI quality and how it can negatively impact patient care have become apparent.
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