Publications by authors named "J C Vollmer"

Article Synopsis
  • Intrathecal drug administration is a promising method for delivering biologics to the central nervous system (CNS), but there is limited knowledge on how well intrathecally applied antibodies are tolerated and their pharmacokinetics.
  • This study involved administering a human monoclonal antibody against Nogo-A to non-human primates, assessing toxicity, pharmacokinetics, and pharmacodynamics with no observed side effects, indicating good tolerability.
  • Findings showed that the antibody was rapidly cleared from the cerebrospinal fluid but accumulated in the serum, effectively targeting Nogo-A in the CNS, which could enhance therapeutic strategies for CNS diseases.
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Background: Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects 6-12% of United States women of reproductive age. Because women with PCOS are at an increased risk of developing type 2 diabetes, clinical practice guidelines from a number of organizations (e.g.

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Obligate intracellular endobacteria of the genus are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy with antibiotics are based on this important endosymbiont. Investigating , however, is impeded by the need for host cells.

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Introduction: Phenotypic complexity in species complexes and recently radiated lineages has resulted in a diversity of forms that have historically been classified into separate taxa. Increasingly, with the proliferation of high-throughput sequencing methods, additional layers of complexity have been recognized, such as frequent hybridization and reticulation, which may call into question the previous morphological groupings of closely related organisms.

Methods: We investigated Northern European, Asian, and Beringian populations of agg.

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Background: Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects 6-12% of United States women of reproductive age. Women with PCOS are at an increased risk of developing type 2 diabetes and fall into high-risk groups according to the American College of Obstetricians and Gynecologists (ACOG) screening guidelines. Guidelines further indicate that an oral glucose tolerance test (OGTT) should be used for diabetes screening in women with PCOS instead of an A1C or fasting plasma glucose test.

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