Publications by authors named "J C Van Meurs"
Objective: To study the association between various radiographic definitions of acetabular dysplasia (AD) and incident radiographic hip osteoarthritis (RHOA), and to analyze in subgroups.
Methods: Hips free of RHOA at baseline and with follow-up within 4-8 years were drawn from the World COACH consortium. The Wiberg center edge angle (WCEA), acetabular depth width ratio (ADR), and the modified acetabular index (mAI) were calculated.
Objectives: Previous genetic and animal studies indicated a causal role of thyroid hormones in osteoarthritis (OA), which has not been observed in the general population. We aimed to investigate whether thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were associated with hand, hip, or knee OA.
Methods: Participants from the Rotterdam Study with baseline TSH, FT4, and joint radiographs were included.
Article Synopsis
- This study investigates the link between an epigenetic risk score (ERS) related to alcohol consumption and blood pressure traits, finding significant associations between higher ERS and increased blood pressure levels among participants.
- In the analysis of 3,898 individuals from the Framingham Heart Study, each unit increase in the ERS correlated with a rise in systolic blood pressure (SBP) by almost 2 mm Hg and diastolic blood pressure (DBP) by about 0.68 mm Hg.
- The research suggests that the ERS could serve as a useful tool for assessing cardiovascular risks linked to alcohol consumption, especially in cases where self-reported data may be unreliable.
DXA images vs. pelvic radiographs: Reliability of hip morphology measurements.
Osteoarthritis Cartilage
October 2024
Objective: Dual-energy x-ray absorptiometry (DXA) images are increasingly used to study hip morphology. Whether hip morphology measurements are consistent between DXA images and radiographs is unknown. Therefore, we investigated the agreement and reliability of the measurements performed on DXA images and radiographs.
View Article and Find Full Text PDFArticle Synopsis
- MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in regulating gene expression and may serve as biomarkers for various diseases through their presence in plasma.
- The study analyzed 2083 plasma circulating miRNAs from participants in the Rotterdam Study, uncovering 3292 associations between SNPs and miRNAs, with a significant portion confirmed in further studies.
- Findings suggest that specific miRNAs can influence a range of clinical conditions, with miR-1908-5p showing a protective effect against benign colon neoplasm, highlighting the potential for miRNA-targeted therapies in medicine.