Publications by authors named "J C Vallve"
Backgrounds And Aims: Preclinical studies suggest that a triglyceride (TG)-independent proinflammatory action of apolipoprotein C-III (apoCIII) exists. We aimed to investigate the relationship between circulating apoCIII levels and subclinical inflammation markers across different cohorts with distinctive inflammatory patterns: patients with metabolic disorders (MDs), patients with rheumatoid arthritis (RA), and controls. Specifically, we assessed the associations of apoCIII with acute inflammation biomarkers (e.
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- Rheumatoid arthritis (RA) is a chronic autoimmune disease linked to joint pain and disabilities, and ongoing research is examining its connection with cardiovascular (CV) disease.
- A study involving 219 RA patients, some with metabolic disorders, focused on measuring specific microRNAs and glycoproteins to understand their roles in inflammation related to RA and CV health.
- Findings revealed that RA patients had higher levels of glycoproteins compared to controls, which were correlated with inflammatory markers and certain miRNAs, suggesting that these glycoproteins may indicate RA severity and are related to both inflammation and CV disease.
Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD), which is attributed to inflammatory processes that accelerate atherosclerosis. Therefore, the exploration of novel biomarkers association is needed. This study investigated the associations between serum trace elements (Fe, Zn, Mg, Se, and Sr) and surrogate markers of CVD in 219 RA patients and compared them with those with metabolic disorders (MetD, n = 82) and control participants (n = 64).
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- Rheumatoid arthritis (RA) is a chronic autoimmune disease that increases the risk of cardiovascular disease (CVD), and this study focused on evaluating new cardiovascular biomarkers in RA patients.
- Researchers assessed 199 RA patients for CVD risk factors, disease activity, and levels of biomarkers like fetuin-A and catestatin, finding significant correlations between these biomarkers and RA parameters.
- While elevated levels of catestatin and fetuin-A showed some associations with rheumatoid factor positivity and other disease markers, no significant links were found to traditional CVD measures like carotid intima-media thickness, indicating a need for more research on these biomarkers' roles in RA.
This prospective observational study compared the 1H NMR blood lipidomes and metabolomes of 71 patients with community-acquired pneumonia (CAP), 75 patients with COVID-19 pneumonia, and 75 healthy controls (matched by age and sex) to identify potential biomarkers and pathways associated with respiratory infections. Both pneumonia groups had comparable severity indices, including mortality, invasive mechanical ventilation, and intensive care unit admission rates. Patients with COVID-19 pneumonia exhibited more pronounced hypolipidemia, with significantly lower levels of total cholesterol and LDL-c compared to patients with CAP.
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