Publications by authors named "J C Thiranos"
Introduction: The aim of this study was to collect data in France in patients with heparin-induced thrombocytopenia who required parenteral anticoagulation and for whom other non-heparin anticoagulant therapies were contraindicated including patients with renal failure, cross-reactivity to danaparoid or at high hemorrhagic risk.
Methods: A total of 20 patients, of mean age 72 ± 10 years, were enrolled in this open-label, multicenter clinical study. Exploratory statistical data analysis was performed with descriptive interpretation of intra-individual comparisons using simple univariate statistics.
Rationale: Post-cardiac surgery shock is associated with high morbidity and mortality. By removing toxins and proinflammatory mediators and correcting metabolic acidosis, high-volume hemofiltration (HVHF) might halt the vicious circle leading to death by improving myocardial performance and reducing vasopressor dependence.
Objectives: To determine whether early HVHF decreases all-cause mortality 30 days after randomization.
Article Synopsis
- This study investigates the relationship between fibrinogen levels and postoperative bleeding in cardiac surgery patients who underwent cardiopulmonary bypass, involving 1,956 participants.* -
- It found that patients with excessive bleeding had lower fibrinogen levels upon admission to the ICU, with a significant correlation between Day 0 fibrinogen levels and chest tube output within the first 24 hours.* -
- The research concluded that fibrinogen levels measured on the day of ICU admission can effectively predict the risk of excessive postoperative bleeding, suggesting a potential need for using fibrinogen concentrates to manage blood loss.*
Background: Unfractionated heparin has been the standard anticoagulant used immediately after mechanical heart valve replacement (MHVR). The purpose of this study was to assess a postoperative anticoagulation protocol with low-molecular-weight heparin (LMWH) immediately after MHVR without the use of unfractionated heparin or anti-factor Xa monitoring.
Methods: We performed a prospective, single-center, observational study of 1,063 consecutive patients undergoing elective MHVR with postoperative LMWH anticoagulation treatment.
Heparin-induced thrombocytopenia (HIT), is a severe side effect of heparin. It occurs both in patients treated with unfractionated heparin (UFH) and in patients treated with low molecular weight heparin (LMWH). It is associated with anti-heparin/platelet factor (PF4) antibodies.
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