Publications by authors named "J C Thiery"
Hypophosphatasemia (HPE) may be temporary (tHPE) in the context of severe diseases, such as sepsis or trauma, or it may persist (pHPE), indicating an adult form of hypophosphatasia (HPP; OMIM 171760), a rare metabolic bone disorder caused by pathogenic nucleotide variants (PNVs) in the . The aim of this study was to analyze the role of auxiliary general biomarkers in verifying low alkaline phosphatase (ALP) serum activity level as an alert parameter for PNVs in the , which are indicative of HPP. In this retrospective analysis, we examined adult patients with an ALP serum activity level below 21 U/L.
View Article and Find Full Text PDFAnti-angiogenic inhibitors and immune checkpoint blockade combination therapy offers a novel approach to circumvent the challenges associated with limited responsiveness to checkpoint inhibitors in bladder cancer. However, the effective strategies for inhibiting angiogenesis in bladder cancer need further elucidation. This work aims to identify key targets for the effective inhibition of angiogenesis in bladder cancer and to explore the potential benefits of combining anti-angiogenic therapies with immune checkpoint blockade strategies in the treatment of this disease.
View Article and Find Full Text PDFBackground/aim: During low anterior rectal resection for rectal cancer, a protective ileostomy (PI) is routinely created to reduce the severity of anastomotic complications. The aim of this study was to investigate the side-effects of PI during adjuvant chemotherapy.
Patients And Methods: A retrospective cohort of patients was operated on for non-metastatic rectal cancer with a PI during 2005-2022.
Article Synopsis
- Resistance to DNA-damaging chemotherapy in breast cancer is linked to high levels of the protein TRPS1, which is associated with reduced drug effectiveness and poor patient outcomes.
- * TRPS1 enhances the activity of DNA damage repair mechanisms in cancer cells and is involved in repairing DNA breaks through its association with other repair proteins.
- * Targeting TRPS1 could potentially improve the effectiveness of chemotherapy for breast cancer patients by overcoming their resistance to treatment.