Publications by authors named "J C Teran"
Checkpoint kinases 1 and 2 (CHK1 and CHK2) are enzymes that are involved in the control of DNA damage. At the present time, these enzymes are some of the most important targets in the fight against cancer since their inhibition produces cytotoxic effects in carcinogenic cells. This paper proposes the use of spirostans (Sp), natural compounds, as possible inhibitors of the enzymes CHK1 and CHK2 from an in silico analysis of a database of 155 molecules (S5).
View Article and Find Full Text PDFArticle Synopsis
- - This research examined how heat affects the upper body of firefighters and their protective gear after intense heat exposure, confirming a hypothesis that the head and helmet would be the hottest areas.
- - Twenty participants exercised for 21 minutes in a humid and hot environment while wearing firefighter gear, with various body parts and PPE analyzed for temperature.
- - Results showed the head, chest, and upper back were the hottest post-exercise, while the abdomen was the coolest, highlighting the need for better cooling strategies for firefighters.
Introduction: There are limited longitudinal data on the systemic and mucosal antibody responses to SARS-CoV-2 from Latin America, a region severely affected by COVID-19, and where vaccine strategies have been implemented during the evolving pandemic.
Objective: To evaluate determinants of seroprevalence and changes in levels of anti-SARS-CoV-2 antibodies longitudinally in adults with different levels of exposure to SARS-CoV-2 (defined as low, medium, and high based on presumed occupational risk), in two Andean cities in Ecuador.
Methods: Longitudinal cohort study of 1,000 adults aged 18 years and older with questionnaire data and sample collection done at 0, 3, 6, and 12 months during the period 2020-2023.
We demonstrate that α-(aminomethyl)acrylates are suitable acceptors for 1,4-additions of dialkylzincs in aerobic conditions. The air-promoted radical-polar crossover process involves the 1,4-addition of an alkyl radical followed by homolytic substitution at the zinc atom of dialkylzinc. Coordination of the nitrogen atom to zinc enables this S2 process which represents a rare example of alkylzinc-group transfer to a tertiary α-carbonyl radical.
View Article and Find Full Text PDF