Publications by authors named "J C Tanaka"
Application of model-informed drug development (MIDD) for dose selection in regulatory submissions for drug approval in Japan.
J Pharmacokinet Pharmacodyn
January 2025
Model-informed drug development (MIDD) is an approach to improve the efficiency of drug development. To promote awareness and application of MIDD in Japan, the Data Science Expert Committee of the Drug Evaluation Committee in the Japan Pharmaceutical Manufacturers Association established a task force, which surveyed MIDD applications for approved products in Japan. This study aimed to reveal the trends and challenges in the use of MIDD by analyzing the survey results.
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- Recent research highlights the prognostic significance of differences between creatinine-based and cystatin C-based estimated glomerular filtration rates (eGFR) but lacks focus on the impact of protein intake on these differences.
- The study analyzed data from over 6,000 participants in Japan to explore the relationship between dietary protein consumption and eGFR discordance, evaluating results separately for men and women due to varying dietary patterns.
- Findings revealed that higher total protein intake, particularly from animal sources in men, was linked to increased eGFR discordance, suggesting that dietary factors should be considered in future research on eGFR-related health outcomes.
High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.
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- The study examined the link between dietary calcium intake and the occurrence of falls in adults aged 40 and older.
- Results showed that lower calcium intake correlated with a higher risk of falls, with significant odds ratios indicating this association for both men and women.
- The findings suggest that ensuring adequate dietary calcium may help reduce the incidence of falls in older adults.
Hepatitis B and C (HBV and HCV) testing has been performed in Japan since 2002 and is subsidized by central and prefectural governments. A follow-up program for HBV- or HCV-infected persons was started at that time in Ishikawa Prefecture. This study analyzed the long-term follow-up data from this program.
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