Publications by authors named "J C Stolk"
Background & Aims: Homozygous Pi∗Z mutation in alpha-1 antitrypsin (Pi∗ZZ genotype) predisposes to pulmonary loss-of-function and hepatic gain-of-function injury. To facilitate selection into clinical trials typically targeting only 1 organ, we systematically evaluated an international, multicenter, longitudinal, Pi∗ZZ cohort to uncover natural disease course and surrogates for future liver- and lung-related endpoints.
Methods: Cohort 1 recruited 737 Pi∗ZZ individuals from 25 different centers without known liver comorbidities who received a baseline clinical and laboratory assessment as well as liver stiffness measurement (LSM).
Emphysema in patients with chronic obstructive pulmonary disease (COPD) is characterized by progressive inflammation. Preclinical studies suggest that lung volume reduction surgery (LVRS) and mesenchymal stromal cell (MSC) treatment dampen inflammation. We investigated the effects of bone marrow-derived MSC (BM-MSC) and LVRS on circulating and pulmonary immune cell profiles in emphysema patients using mass cytometry.
View Article and Find Full Text PDFBackground: Biliary atresia (BA) is a rare condition of unknown origin in newborns with jaundice. In BA bile ducts are non-functional, causing neonatal cholestasis and following liver fibrosis and failure.
Methods: This retrospective study included liver biopsies of 14 infants with BA aged [mean ± SD] 63 ± 23 days.
High-Dimensional Mass Cytometry Reveals Emphysema-associated Changes in the Pulmonary Immune System.
Am J Respir Crit Care Med
October 2024
Article Synopsis
- Chronic inflammation is linked to tissue damage in emphysema, but the specific immune changes and cell interactions need further investigation.
- Researchers used advanced techniques (single-cell mass cytometry and imaging mass cytometry) to analyze immune cells in lung tissue from patients with severe emphysema compared to healthy controls.
- They found distinct differences in immune cell types and interactions, highlighting higher central memory CD4 and CD8 T cells in emphysema, which could provide insights into the disease's mechanisms and potential treatment targets.