Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation.

Background: Multiple Myeloma (MM) is the second most common hematological malignancy, characterized by the accumulation of monoclonal plasmocytes in the bone marrow. Despite advancements with proteasome inhibitors, immunomodulatory agents, and CD38-targeting antibodies, MM remains largely incurable due to resistant clones and frequent relapses. The success of the proteasome inhibitor bortezomib (BTZ) in MM treatment highlights the critical role of the ubiquitin-proteasome system (UPS) in this disease.

Vertebral fracture in a fused spine for scoliosis. A case report.

Study Design: A case report.

Objectives: To document a fracture of the 11th thoracic vertebra after spine fusion for adult idiopathic scoliosis.

Summary Of Background Data: Three cases of vertebral fractures associated with spine fusion for scoliosis were found in the literature.

Contralateral median nerve autograft.

Interfascicular nerve autografting is a useful method to repair nerves with gaps, mainly if the removal of a nerve does not imply a defect to the donor area. Final results of peripheral nerve repair definitely depend on the size of the nerve gap, the level of the injury and the time elapsed from the time of injury until the nerve is repaired.

Surgical treatment of coarctation of the aorta in the first year of life. Immediate and late results in 35 patients.

Between February 1974 and September 1981, 35 consecutive infants younger than 12 months underwent repair of coarctation of the aorta. The mean age was 57 days and 24 were younger than 60 days. The indications for operation were congestive heart failure, metabolic acidosis and severe systemic hypertension.