Publications by authors named "J C Schrama"
Article Synopsis
- The study examined how different diets for European seabass affect the composition of their faeces, particularly focusing on the nutrients that remain undigested and the potential for those faeces to produce organic acids through anaerobic digestion.
- Researchers tested faecal samples from six different diets in anoxic conditions to analyze nutrient solubilization and the yield of organic acids over a 14-day period.
- Findings indicated that faeces with higher protein relative to carbohydrates produced more organic acids, especially acetate, while the overall bacterial diversity in the faeces remained similar despite some variations in specific genera.
Acid ceramidase (Ac) is a lysosomal enzyme catalyzing the generation of sphingosine from ceramide, and Ac inhibitors are currently being investigated as potential cancer therapeutics. Yet, the role of the Ac in immune responses, particularly anti-viral immunity, is not fully understood. To investigate the impact of Ac expression on various leukocyte populations, we generated a tamoxifen-inducible global knockout mouse model for the Ac (iAc-KO).
View Article and Find Full Text PDFExploratory analyses of high-dose alkylating chemotherapy trials have suggested that BRCA1 or BRCA2-pathway altered (BRCA-altered) breast cancer might be particularly sensitive to this type of treatment. In this study, patients with BRCA-altered tumors who had received three initial courses of dose-dense doxorubicin and cyclophosphamide (ddAC), were randomized between a fourth ddAC course followed by high-dose carboplatin-thiotepa-cyclophosphamide or conventional chemotherapy (initially ddAC only or ddAC-capecitabine/decetaxel [CD] depending on MRI response, after amendment ddAC-carboplatin/paclitaxel [CP] for everyone). The primary endpoint was the neoadjuvant response index (NRI).
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- The study examined how the toxic effects of deoxynivalenol (DON) from Fusarium graminearum in rainbow trout were influenced by co-exposure to toxins from Fusarium verticillioides (FU).
- The experimental design included four different diets to assess growth performance and liver/gastrointestinal histopathology over an 8-week period.
- Results showed that both DON and FU independently hindered growth and increased feed conversion ratio, without any interaction effects between the two toxins.
This study with juvenile rainbow trout evaluated the effects of dietary exposure to deoxynivalenol (DON) at industrially relevant doses (up to 1.6 mg/kg) on growth performance, the liver, and the gastrointestinal tract. Fifteen groups of 30 fish each were given one of five dietary treatments in triplicate: (1) control diet (CON; DON < 100 µg/kg feed), (2) naturally DON-contaminated diet (ND1) with a DON content of 700 µg/kg in the feed, (3) ND2 with a DON content of 1200 µg/kg feed, (4) a pure DON-contaminated diet (PD1) with 800 µg/kg of DON in the feed, and (5) PD2 with DON at a concentration of 1600 µg/kg in the feed.
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