Preferences on treatment decision making in sarcoma patients. Prevalence and associated factors - Results from the PROSa Study.

Introduction: The impact of being diagnosed with a life-threatening illness may influence preferences to participate in treatment decisions. The objective of this analysis was to identify factors that are associated with sarcoma patients wanting to take a more active or passive role.

Methods: Data was obtained as part of a nationwide multicenter study (PROSa) aiming to investigate the structure and quality of medical care of sarcoma patients in Germany and their determinants.

Development of a pandemic-related core set of quality indicators for quality and patient safety in University Hospitals in Germany.

Background: The COVID-19 pandemic entailed a global health crisis, significantly affecting medical service delivery in Germany as well as elsewhere. While intensive care capacities were overloaded by COVID cases, not only elective cases but also non-COVID cases requiring urgent treatment unexpectedly decreased, potentially leading to a deterioration in health outcomes. However, these developments were only uncovered retrospectively.

Selective Protein (Post-)modifications through Dynamic Covalent Chemistry: Self-activated SAr Reactions.

SAr reactions were remarkably accelerated using a pretargeting and activating unit based on dynamic covalent chemistry (DCvC). A Cys attack at the C-F bond on the aromatic ring of salicylaldehyde derivatives was only observed upon iminium formation with a neighboring Lys residue of model small peptides. Such self-activation was ascribed to the stronger electron-withdrawing capability of the iminium bond with respect to that of the parent aldehyde that stabilized the transition state of the reaction, together with the higher preorganization of the reactive groups in the cationic aldiminium species.

Abrupt changes in biomass burning during the last glacial period.

Understanding the causes of past atmospheric methane (CH) variability is important for characterizing the relationship between CH, global climate and terrestrial biogeochemical cycling. Ice core records of atmospheric CH contain rapid variations linked to abrupt climate changes of the last glacial period known as Dansgaard-Oeschger (DO) events and Heinrich events (HE). The drivers of these CH variations remain unknown but can be constrained with ice core measurements of the stable isotopic composition of atmospheric CH, which is sensitive to the strength of different isotopically distinguishable emission categories (microbial, pyrogenic and geologic).