Publications by authors named "J C Sandbank"
Article Synopsis
- The study aimed to assess the accuracy of a fully automated AI solution for interpreting HER2 immunohistochemistry (IHC) in breast cancer, acknowledging the need for more reliable HER2 scoring due to the effectiveness of HER2-targeted therapies.
- In a two-arm study involving 120 HER2 IHC whole-slide images and four surgical pathologists, the AI solution showed improved interobserver agreement and scoring accuracy compared to manual readings, particularly for distinguishing between HER2 0 and 1+ cases.
- The results indicate that the AI tool can enhance the consistency and reproducibility of HER2 scoring, supporting pathologists in following ASCO/CAP guidelines more effectively.
Breast cancer is the most common malignant disease worldwide, with over 2.26 million new cases in 2020. Its diagnosis is determined by a histological review of breast biopsy specimens, which can be labor-intensive, subjective, and error-prone.
View Article and Find Full Text PDFThe systemic anti-cancer approach is based on medical/pharmaceutical interventions affecting cancer cells at multiple sites, including local and distant regions. Interventions include: cytotoxic chemotherapy agents used for direct extermination of proliferating cells, hormonal interventions altering the tumor environment and affecting its ability to survive and thrive, biological drugs restoring the function defective proteins in mutated tumors, and immunological medications encouraging effective immune recognition of tumor cells and associated immune response. "Personalized medicine in oncology" aims to make anti-cancer treatment more effective and with less side effects.
View Article and Find Full Text PDFBiplanar Lipoabdominoplasty: Introducing the Subscarpal Lipo Aponeurotic System.
Plast Reconstr Surg Glob Open
January 2022
Unlabelled: Preservation of Scarpa's fascia in abdominoplasty has been previously presented. Herein we introduce the subscarpal lipo aponeurotic system (SLAS) and the technique of preserving the SLAS and its tightening in lipoabdominoplasty.
Methods: A retrospective cohort study of patients who underwent lipoabdominoplasty performed by a single plastic surgeon (YW) between 2014 and 2019 was conducted.
Objectives: This work is aimed to summarize the first year of the high-risk human papillomavirus (hrHPV) screening test and compare it to the cytology screening test, regarding positivity rates and premalignant lesions diagnosed in the Israeli population. A specific consideration is for the age group 25-30 that is not considered mandatory for the HPV primary screening testing.
Methods: A retrospective study was performed in women who were screened for prevention of cervical cancer in Maccabi HealthCare HMO from March 2017 to March 2019.