Evaluation of an 8-week telehealth cognitive-behavioural therapy (CBT) program for adults with muscle dysmorphia: A pilot and feasibility study.

Muscle dysmorphia (MD) is a psychological disorder defined by a pathological belief that one lacks muscularity and has excess body fat. To date, treatment research on MD has been sparse. We conducted a pilot feasibility and acceptability study investigating the preliminary efficacy of an 8-week telehealth cognitive-behavioural therapy (CBT) intervention for adults with diagnosed MD.

Can artificial intelligence improve patient educational material readability? A systematic review and narrative synthesis.

Enhancing patient comprehension of their health is crucial in improving health outcomes. The integration of artificial intelligence (AI) in distilling medical information into a conversational, legible format can potentially enhance health literacy. This review aims to examine the accuracy, reliability, comprehensiveness and readability of medical patient education materials (PEMs) simplified by AI models.

Circulating cytokine associations with clinical outcomes in melanoma patients treated with combination nivolumab plus ipilimumab.

Nivolumab plus ipilimumab (aCTLA-4/aPD-1) combination therapy has significantly improved clinical outcomes in patients with metastatic melanoma, with 50%-60% of patients responding to treatment, but predictors of response are poorly characterized. We hypothesized that circulating cytokines and peripheral white blood cells may predict response to therapy and evaluated 15 cytokines and complete blood counts (CBC with differentials) from 89 patients with advanced melanoma treated with combination therapy from three points in time: pre-treatment, one month and approximately three months after starting therapy. Clinical endpoints evaluated included durable clinical benefit (DCB), progression-free survival (PFS), and overall survival (OS).

Testing bipolarity.

Many psychological dimensions seem bipolar (e.g., happy-sad, optimism-pessimism, and introversion-extraversion).

Metabolic features that select for Bathyarchaeia in modern ferruginous lacustrine subsurface sediments.

Ferruginous conditions prevailed through Earth's early oceans history, yet our understanding of biogeochemical cycles in anoxic iron-rich, sulfate-poor sediments remains elusive in terms of redox processes and organic matter remineralization. Using comprehensive geochemistry, cell counts, and metagenomic data, we investigated the taxonomic and functional distribution of the microbial subsurface biosphere in Lake Towuti, a stratified ferruginous analogue. Below the zone in which pore water becomes depleted in electron acceptors, cell densities exponentially decreased while microbial assemblages shifted from iron- and sulfate-reducing bacterial populations to fermentative anaerobes and methanogens, mostly selecting Bathyarchaeia below the sulfate reduction zone.