Publications by authors named "J C Rodriguez-Sanjuan"
Background: Several scores have been developed to stratify the risk of graft loss in controlled donation after circulatory death (cDCD). However, their performance is unsatisfactory in the Spanish population, where most cDCD livers are recovered using normothermic regional perfusion (NRP). Consequently, we explored the role of different machine learning-based classifiers as predictive models for graft survival.
View Article and Find Full Text PDFThoracoabdominal (TA) normothermic regional perfusion (NRP) should allow the safe recovery of heart and liver grafts simultaneously in the context of controlled donation after circulatory death (cDCD). We present the initial results of cDCD liver transplantation with simultaneous liver and heart procurement in Spain until October 2021. Outcomes were compared with a matched cohort of cDCD with abdominal NRP (A-NRP) from participating institutions.
View Article and Find Full Text PDFSurvival analysis of the surgical treatment of hepatocellular carcinoma at a tertiary care center.
Rev Gastroenterol Mex (Engl Ed)
August 2024
Introduction And Aims: Hepatocellular carcinoma (HCC) is a primary malignant tumor of liver epithelial cells and is the most frequent primary liver cancer. The broadening of transplantation and resectability criteria has made therapeutic decisions more complex. Our aim was to describe the clinical and survival characteristics of patients with HCC treated through resection or liver transplantation at our hospital and identify the presence of factors that enable outcome prediction and facilitate therapeutic decision-making.
View Article and Find Full Text PDFArticle Synopsis
- * Conducted between June 2019 and August 2020, the retrospective analysis involved 40 hospitals, with insights derived from over 2,200 liver surgeries, including 1350 for colorectal metastases, of which 150 utilized the liver-first strategy.
- * Findings revealed no significant differences in surgical outcomes between hospitals performing fewer than 50 versus those performing 50 or more liver surgeries per year, prompting further research into optimal candidate selection for this treatment approach.
Article Synopsis
- KRAS mutation negatively impacts survival outcomes for patients with colorectal liver metastases, with those having mutated KRAS showing significantly shorter overall and disease-free survival compared to those with wild-type KRAS.
- The study analyzed data from 593 patients to compare the effects of R0 (no cancer at margins) and R1 (cancer at margins) resections based on KRAS status, finding that R0 resections benefit wild-type patients but not those with KRAS mutations.
- In KRAS wild-type tumors, R0 resections were linked to longer survival, while in KRAS-mutated tumors, the resection margin did not influence outcomes, emphasizing the aggressive nature of KRAS-mutated cancers.