Publications by authors named "J C Reijneveld"
αβ T cell receptors (αβTCRs) co-recognise antigens when bound to Major Histocompatibility Complex (MHC) or MHC class I-like molecules. Additionally, some αβTCRs can bind non-MHC molecules, but how much intact antigen reactivities are achieved remains unknown. Here, we identify an αβ T cell clone that directly recognises the intact foreign protein, R-phycoerythrin (PE), a multimeric (αβ)γ protein complex.
View Article and Find Full Text PDFBackground: Neurocognitive impairments are common in patients with a brain tumour, and may negatively impact on functioning in daily life, particularly on instrumental activities of daily living (IADL). The EORTC IADL-BN32 questionnaire was developed to measure IADL in this patient population.
Methods: In this international validation study, we evaluated the EORTC IADL-BN32 questionnaire on several psychometric properties in a large sample of patients with a primary or metastatic brain tumour.
Tuberculosis (TB) is a leading cause of mortality from an infectious disease. In this opinion article, we focus on accumulating scientific evidence indicating that viral infections may contribute to TB progression, possibly allowing novel preventive interventions. Viruses can remodel the mammalian immune system, potentially modulating the risk of reactivating latent microbes such as Mycobacterium tuberculosis (Mtb).
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- - The study focused on developing and preliminarily validating the Scale for Objective Diagnostic Components of Paroxysmal Events (STAMP), which categorizes seizure-like events, including epileptic seizures, functional seizures, and syncope.
- - Researchers analyzed data from 200 patients referred to a Dutch epilepsy center, noting that 131 had epileptic seizures, 17 had functional seizures, and findings indicated significant diagnostic improvements through various event recordings during follow-up.
- - The findings suggest that regular monitoring through STAMP can enhance diagnostic accuracy, although further validation of the scale is needed to fully establish its effectiveness.
A quarter of humanity is estimated to have been exposed to Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing tuberculosis (TB) disease. Variability in responses to Mtb infection could be due to host or pathogen heterogeneity. Here, we focused on host genetic variation in a Peruvian population and its associations with gene regulation in monocyte-derived macrophages and dendritic cells (DCs).
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