Publications by authors named "J C Perin"
This study investigated whole-cell oral cholera vaccine (kOCV) single-dose effectiveness and transmission dynamics of through 4 years of epidemiological and genomic surveillance in Democratic Republic of the Congo (DRC). Whole genome sequencing was performed on clinical and water strains from 200 patient households and found annual bimodal peaks of clade AFR10e. 1154 diarrhea patients were enrolled with 342 culture confirmed cholera patients.
View Article and Find Full Text PDFBackground: The aim of this prospective cohort study is to build evidence on transmission dynamics and risk factors for infections in cholera patient households.
Methods: Household contacts of cholera patients were observed for 1-month after the index cholera patient was admitted to a health facility for stool, serum, and water collection in urban Bukavu in South Kivu, Democratic Republic of the Congo. A infection was defined as a bacterial culture positive result during the 1-month surveillance period and/or a four-fold rise in a O1 serological antibody from baseline to the 1-month follow-up.
Article Synopsis
- Patients with diabetes face higher mortality rates from COVID-19, and while dexamethasone is commonly used to treat severe cases, it may negatively impact blood sugar levels, necessitating a closer look into its effects in this population.
- This study analyzed data from over 3,600 hospitalized diabetic patients with COVID-19 to compare outcomes between those treated with dexamethasone and those who weren't.
- The findings revealed no significant differences in survival rates or time to recovery between the two groups, indicating that dexamethasone may not be beneficial for diabetic patients with COVID-19 and highlighting the need for further research.
Article Synopsis
- The study investigates small bowel issues in systemic sclerosis (SSc) patients, finding that around 50% of these patients are affected, often severely.
- Using statistical analysis, researchers compared clinical characteristics of SSc patients with and without small bowel abnormalities, revealing that those with issues were more likely to be male, had worse cardiac problems, and lower rates of dry mouth/eyes (sicca symptoms).
- The study concludes that recognizing patients with abnormal small bowel transit can help in risk assessment and improving patient care, as these individuals showed higher mortality rates.
Objectives: Among participants with Alzheimer's disease (AD) we estimated the minimal clinically important difference (MCID) in apathy symptom severity on three scales.
Design: Retrospective anchor- and distribution-based analyses of change in apathy symptom scores.
Setting: Apathy in Dementia Methylphenidate Trial (ADMET) and ADMET 2 randomized controlled trials conducted at three and ten clinics specialized in dementia care in United States and Canada, respectively.