Publications by authors named "J C Perez-Pons"
Article Synopsis
- - Moonlighting proteins are single polypeptide chains that have evolved to perform multiple functions, with over 78% linked to human diseases and many being potential drug targets.
- - These proteins can activate different functions under pathological conditions, either promoting or combating diseases, particularly in processes like inflammation and cancer.
- - Understanding the specific roles of moonlighting proteins in disease progression is crucial for developing effective treatments, as their functions can impact a patient's health in complex ways.
Moonlighting and multitasking proteins refer to proteins with two or more functions performed by a single polypeptide chain. An amazing example of the Gain of Function (GoF) phenomenon of these proteins is that 25% of the moonlighting functions of our Multitasking Proteins Database (MultitaskProtDB-II) are related to pathogen virulence activity. Moreover, they usually have a canonical function belonging to highly conserved ancestral key functions, and their moonlighting functions are often involved in inducing extracellular matrix (ECM) protein remodeling.
View Article and Find Full Text PDFMultifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases and drug targeting. The analysis of the proportion of multitasking proteins from the MultitaskProtDB-II database shows that 78% of the proteins analyzed are involved in human diseases.
View Article and Find Full Text PDFMoonlighting or multitasking proteins refer to those proteins with two or more functions performed by a single polypeptide chain. Proteins that belong to key ancestral functions and metabolic pathways such as primary metabolism typically exhibit moonlighting phenomenon. We have collected 698 moonlighting proteins in MultitaskProtDB-II database.
View Article and Find Full Text PDFMultitasking, or moonlighting, is the capability of some proteins to execute two or more biological functions. MultitaskProtDB-II is a database of multifunctional proteins that has been updated. In the previous version, the information contained was: NCBI and UniProt accession numbers, canonical and additional biological functions, organism, monomeric/oligomeric states, PDB codes and bibliographic references.
View Article and Find Full Text PDF