Publications by authors named "J C P Kingdom"
Objectives: Acute histological chorioamnionitis (HCA) is detected in over 50% of spontaneous preterm birth (PTB) and is associated with worse neonatal prognosis. We aim to investigate whether the presence of HCA impacts subsequent pregnancy outcomes.
Methods: This retrospective cohort study included deliveries at a tertiary centre from 2014 to 2020.
Importance: Early preterm birth (ie, at less than 34 weeks' gestation) confers a high risk for adverse health outcomes, yet no universal screening strategy exists, preventing targeted delivery of effective interventions.
Objective: To evaluate the ability of midpregnancy placental growth factor (PlGF) screening to identify pregnancies at highest risk for early preterm birth.
Design, Setting, And Participants: This prospective cohort study was conducted at an urban, tertiary care center from 2020 to 2023.
Objective: To predict birth weight at various potential gestational ages of delivery based on data routinely available at the first antenatal visit.
Design: Individual participant data meta-analysis.
Data Sources: Individual participant data of four cohorts (237 228 pregnancies) from the International Prediction of Pregnancy Complications (IPPIC) network dataset.
Background: Our objective was to investigate the predictive and diagnostic accuracy of the angiogenic proteins sFlt-1 (soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor) for preterm preeclampsia and explore the relationship between renal function and these proteins.
Methods: We completed a blinded, prospective, longitudinal, observational study of patients with chronic kidney disease followed at a tertiary center (2018-2023). Serum samples were obtained at 3 time points along gestation (planned sampling): 12-16, 18-22, and 28-32 weeks.
Article Synopsis
- The study aimed to assess maternal serum levels of placental growth factor (PlGF), ultrasound placental parameters, and clinical outcomes in IVF frozen embryo transfer (FET) pregnancies, comparing those with and without embryo trophectoderm biopsy.
- Results showed that median PlGF levels were lower in the FET biopsy group (614.5 pg/mL) compared to the non-biopsy group (717.0 pg/mL), although this difference was not statistically significant.
- The conclusion suggests a potential link between trophectoderm biopsy and lower PlGF levels, highlighting the need for further research on its impact on placental health.