Publications by authors named "J C NEELY"
Purpose: Neoadjuvant immune checkpoint blockade with nivolumab plus ipilimumab improves overall survival (OS) in non-small cell lung cancer (NSCLC); however, randomized data for resectable lung cancer are limited. We report results from the exploratory concurrently randomized nivolumab plus ipilimumab and chemotherapy arms of the international phase III CheckMate 816 trial.
Methods: Adults with stage IB-IIIA (American Joint Committee on Cancer seventh edition) resectable NSCLC received three cycles of nivolumab once every 2 weeks plus one cycle of ipilimumab or three cycles of chemotherapy (on day 1 or days 1 and 8 of each 3-week cycle) followed by surgery.
Article Synopsis
- Following the detection of a novel highly pathogenic avian influenza virus (HPAIV) H5N1 in Newfoundland in late 2021, Canada ramped up surveillance efforts of wild birds to track the spread of the virus nationwide.* -
- During the first year of surveillance (November 2021-November 2022), over 6,000 sick and dead birds were tested, revealing that 27.4% were positive for HPAIV across various species and regions, particularly in the Atlantic and Central Flyways.* -
- The findings highlighted the need for ongoing monitoring and collaboration, as wild birds serve as both victims and reservoirs of the virus, with a notable prevalence of Eurasian-origin strains identified throughout
Background: Nivolumab plus ipilimumab demonstrated promising clinical activity and durable responses in sorafenib-treated patients with advanced hepatocellular carcinoma (HCC) in the CheckMate 040 study at 30.7-month median follow-up. Here, we present 5-year results from this cohort.
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- Juvenile dermatomyositis (JDM) is an autoimmune disorder in children linked to abnormal immune responses and limited treatment options due to unclear disease mechanisms.
- The study analyzed the blood of JDM patients at various disease stages, revealing that B cells were skewed towards an immature state and T cells showed signs of sustained Th2-mediated inflammation even during inactive disease.
- By using network analysis, researchers found that a heightened type I IFN response across immune cells is connected to dysfunctional processes in CD4+ T cells and cell death regulation in other T cell types, highlighting the complex immune dysregulation in JDM and hinting at potential treatment strategies.
Probabilistic seismic hazard assessments (PSHAs) provide the scientific basis for building codes to reduce damage from earthquakes. Despite their substantial impact, little is known about how well PSHA predicts actual shaking. Recent PSHA for California, Japan, Italy, Nepal, and France appear to consistently overpredict historically observed earthquake shaking intensities.
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