Publications by authors named "J C Mottram"

Tubulin detyrosination has been implicated in various human disorders and is important for regulating microtubule dynamics. While in most organisms this modification is restricted to α-tubulin, in trypanosomatid parasites, it occurs on both α- and β-tubulin. Here, we show that in , a single vasohibin (LmVASH) enzyme is responsible for differential kinetics of α- and β-tubulin detyrosination.

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For the protozoan parasite Leishmania, completion of its life cycle requires sequential adaptation of cellular physiology and nutrient scavenging mechanisms to the different environments of a sand fly alimentary tract and the acidic mammalian host cell phagolysosome. Transmembrane transporters are the gatekeepers of intracellular environments, controlling the flux of solutes and ions across membranes. To discover which transporters are vital for survival as intracellular amastigote forms, we carried out a systematic loss-of-function screen of the L.

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Objective: Although social factors and culture are significant determinants of health in Aboriginal and Torres Strait Islander peoples, little is known academically about key interpersonal and social experiences of this population during the perinatal period, or how early attachments are formed through culture. This study addressed this gap in the literature.

Methods And Measures: A reflexive thematic analysis approach was applied to the data gathered from focus groups (N = 14) held with Aboriginal (N = 7) and Torres Strait Islander (N = 7) mothers and their kinship systems.

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Article Synopsis
  • * In studies, neutrophils from susceptible BALB/c mice produced more NETs when infected compared to the more resistant C57BL/6 mice, who were better at phagocytosis and had genes associated with that process upregulated.
  • * The research suggests that the balance between NET formation and phagocytic activity plays a crucial role in how susceptible different mouse strains are to Leishmania infection, with specific neutrophil subsets contributing to
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A principal component was developed for 91 commonly accessible surfactants for use in surfactant-enabled organic reactions in water, an important approach for sustainable chemical processes. This map was built using 22 experimental and theoretical descriptors relevant to the physicochemical nature of these surfactant-enabled reactions, and advanced principal component analysis algorithms. It is comprised of all classes of surfactants, cationic, anionic, zwitterionic and neutral surfactants, including designer surfactants.

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