Publications by authors named "J C Michalski"
Tight Junctions and Cancer: Targeting Claudin-1 and Claudin-4 in Thyroid Pathologies.
Pharmaceuticals (Basel)
September 2024
Article Synopsis
- Claudins, specifically claudin-1 and claudin-4, are tight junction proteins involved in the progression of thyroid cancers and are potential therapeutic targets.
- The study analyzed 162 thyroid samples from patients with various pathologies, finding distinct expression patterns: goiters had negative claudin-1 and mostly positive claudin-4, while papillary thyroid cancers and adenomas showed positive claudin-1 and claudin-4.
- High expression levels of claudin-1 were linked to poorer overall survival rates in patients, highlighting its role as a prognostic factor and indicating a need for further trials to explore claudin targeting in clinical settings.
Article Synopsis
- - The study investigates how the timing of radiotherapy (RT) after radical prostatectomy influences long-term health-related quality of life (HRQOL) in men with prostate cancer, focusing on sexual, urinary, and bowel health.
- - Researchers analyzed data from two cohorts, comparing outcomes between three groups: men who had just prostatectomy, those who received early RT (within 12 months), and those who had late RT (12 months or later).
- - Findings revealed that men who underwent RT after prostatectomy experienced greater declines in aspects of HRQOL compared to those who did not receive RT, highlighting the potential negative effects of post-surgery radiation timing.
Purpose: Men with localized prostate cancer may receive either photon-based intensity modulated radiation therapy (IMRT) or proton beam therapy (PBT). The PARTIQoL trial (NCT01617161) demonstrates the feasibility of performing a large, multicenter phase 3 randomized trial comparing IMRT with PBT for localized prostate cancer. Here, we report baseline features of patients enrolled on this trial and present strategies to improve feasibility of other similar trials.
View Article and Find Full Text PDFThis paper presents a comparison of two-component ammonia-based inlet atmospheres diluted with either hydrogen (NH/H) or nitrogen (NH/N). Taking advantage of the features of inlet atmospheres diluted with nitrogen and hydrogen, four two-stage processes were designed and carried out, which were juxtaposed with two single-stage processes carried out only in an NH atmosphere. A common parameter of the processes carried out was the same value of nitrogen availability in each process stage.
View Article and Find Full Text PDF