A simple and efficient method to recover isotopically enriched Ni-64 from electrolytic solutions.

Production of Cu via the proton irradiation of Ni, electrodeposited on a suitable backing substrate, remains the most common method to produce this emerging radionuclide. Some unforeseen cases arise when the electrodeposition does not work and the electrolytic solution needs to be reprocessed, but the presence of salt buffers makes it difficult to recover the nickel to prepare a fresh solution. The aim of this work was to develop a simple and efficient method to recover Ni from bath solutions.

Biodistribution and radiation dosimetry of [Cu]copper dichloride: first-in-human study in healthy volunteers.

Background: In recent years, Copper-64 (T = 12.7 h) in the chemical form of copper dichloride ([Cu]CuCl) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer.

Biodistribution in rats and estimates of doses to humans from (64)CuCl2, a potential theranostic tracer.

The aim of this study was to obtain data on the biodistribution of (64)CuCl2 in rats and to obtain estimates of the radiation doses to humans by extrapolating the animal data. MicroPET imaging and biodistribution studies were carried out with Wistar rats, and the doses were estimated with OLINDA/EXM. The lower large intestine wall was found to be the critical organ with an absorbed dose of 139±34 and 125±32µGy/MBq for females and males, respectively.

A simple and efficient method of nickel electrodeposition for the cyclotron production of (64)Cu.

Nickel targets for the cyclotron production of (64)Cu were prepared by electrodeposition on a gold backing from nickel chloride solutions using boric acid as buffer. Parameters studied were nickel chloride and boric acid concentration, temperature and current density. All plating conditions studied were successful obtaining efficiencies of approximately 90% in 2-3 h, reaching almost quantitative plating (>97%) in 10-20 h depending on the current density.