Publications by authors named "J C Magee"
Background Aims: Biliary atresia (BA) entails an inflammatory sclerosing lesion of the biliary tree, with prominent fibrosis in infancy. Previous studies revealed neutrophil-activating IL-8 and neutrophil extracellular traps (NETs) positively correlated with bilirubin and risk of liver transplant. The aims of this study were to determine the mechanism of NET formation (NETosis) in BA and if NETs induce stellate cell activation.
View Article and Find Full Text PDFThe association of human milk intake and outcomes in biliary atresia.
J Pediatr Gastroenterol Nutr
November 2024
Article Synopsis
- Human milk intake may not significantly improve jaundice clearance or native liver survival in infants with biliary atresia, but it is associated with better growth and decreased bilirubin levels after surgery.
- A study analyzed 447 infants, comparing those who received human milk to those on formula, finding some notable differences in growth and microbiome but no major outcomes improvements.
- The findings suggest that while human milk is beneficial for growth in biliary atresia cases, more research is required to fully understand its impact on overall health outcomes.
Introduction: Degenerative cervical myelopathy (DCM) is a syndrome of symptomatic cervical spinal cord compression due to degenerative spinal changes. Until recently there was no formal consensus on exactly which patients are suitable for surgical or conservative management. The AO Spine international guidelines were introduced to address this issue, based on the best available current evidence.
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