Publications by authors named "J C Livesey"

Introduction: Out of hospital cardiac arrest (OHCA) is a common problem. Rates of survival are low and a proportion of survivors are left with an unfavourable neurological outcome. Four models have been developed to predict risk of unfavourable outcome at the time of critical care admission - the Cardiac Arrest Hospital Prognosis (CAHP), MIRACLE, Out of Hospital Cardiac Arrest (OHCA), and Targeted Temperature Management (TTM) models.

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Background: Despite high rates of cardiovascular disease in Scotland, the prevalence and outcomes of patients with cardiogenic shock are unknown.

Methods: We undertook a prospective observational cohort study of consecutive patients with cardiogenic shock admitted to the intensive care unit (ICU) or coronary care unit at 13 hospitals in Scotland for a 6-month period. Denominator data from the Scottish Intensive Care Society Audit Group were used to estimate ICU prevalence; data for coronary care units were unavailable.

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Anticipated sequelae of critical care admission for COVID-19 disease remain unclear. Our Edinburgh-based critical care follow-up service identified patterns with nerve injury in 13 of 35 patients who attended following a critical care admission between 15/03/2020 and 25/12/2020. This included 7 cases of meralgia parasthetica, 1 brachial plexopathy, 2 common peroneal neuropathies and 3 ulnar neuropathies.

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Article Synopsis
  • Striatal adenosine A receptors (ARs) can inhibit dopamine release, with their activity being regulated by astrocytic equilibrative nucleoside transporter 1 (ENT1), which is sensitive to ethanol.
  • In experiments with striatal slices from mice, activating ARs diminished dopamine release, especially at lower stimulation rates, while blocking ARs heightened dopamine release levels, indicating a fundamental tonic inhibition.
  • The study found that inhibiting ENT1 increased adenosine levels, further enhancing AR-mediated inhibition, while ethanol reduced adenosine uptake through ENT1, thus promoting dopamine output dynamics and highlighting the complex role of astrocytes in regulating striatal function under the influence of ethanol.
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