Publications by authors named "J C Liebeskind"
Article Synopsis
- Parasites negatively impact the health of their hosts, leading to long-term health issues and socio-economic consequences, but they may also have helpful immune-regulatory effects for autoimmune diseases.
- Researchers used NAD(P)H fluorescence lifetime imaging on murine intestinal tissue infected with the nematode Heligmosomoides polygyrus to explore the metabolic interactions between hosts and parasites.
- The study identified key metabolic pathways in both the host and parasites, focusing on processes like anaerobic glycolysis and oxidative phosphorylation, while also highlighting the immune defense mechanisms at play during infection.
Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In this study, we combine advanced imaging and spatial transcriptomics to shed light on the local immune response in severe COVID-19. We show that activated adventitial niches are crucial microenvironments contributing to the orchestration of prolonged lung immunopathology.
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- Intestinal nematodes pose both health risks and potential benefits, impacting host immunity while causing infections in humans and animals.
- Understanding how these parasites navigate and thrive within their host's intestines is crucial, especially since metabolic processes have been overlooked in past studies.
- Research using specialized imaging techniques has revealed that while hosts maintain energy production through aerobic and anaerobic pathways, nematodes switch between different metabolic strategies depending on their life cycle stage and location within the gut, revealing complex host-parasite interactions.
The present review summarizes the current state of knowledge about the genetics of pain-related phenomena and illustrates the scope and power of genetic approaches to the study of pain. We focus on work performed in our laboratories in Jastrzebiec, Poland; Portland, OR; and Los Angeles, which we feel demonstrates the continuing usefulness of classical genetic approaches, especially when used in combination with newly available molecular genetic techniques.
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