Key epigenetic enzymes modulated by natural compounds contributes to tumorigenicity.

Dysregulation of epigenetic regulation is observed in numerous tumor cells. The therapeutic effects of natural products on tumors were investigated through a comprehensive analysis of active ingredients derived from various structured natural products. The analysis focuses on regulating key enzymes involved in epigenetic control.

Unraveling the interaction of dissolved organic matter and microorganisms with internal phosphorus cycling in the floodplain lake ecosystem.

Internal nutrient cycling, especially phosphorus (P), is of great influence in lake eutrophication. Dissolved organic matter (DOM) and microorganisms are ubiquitous in the sediments and closely associated with P-cycling. However, the underlying interactions of DOM, microorganisms and P in floodplain lake area with different hydrological characteristics remain scarce.

Manure application increases soil doxycycline and zinc levels and resistance gene abundance.

Doxycycline (DOX) and zinc (Zn), are frequently detected in livestock manure. Untreated excrement carries a sizable load of DOX and Zn into the soil, exacerbating agricultural nonpoint source pollution. However, research on the effects of DOX and Zn on soil microbial diversity and the prevalence of resistance genes is limited.

Treatment outcomes among children and adolescents with extensively drug-resistant (XDR) and pre-XDR tuberculosis: Systematic review and meta-analysis.

Extensively drug-resistant (XDR) and pre-XDR- tuberculosis (TB) account for approximately a third of pediatric MDR-TB cases globally. Clinical management is challenging; recommendations are based on limited evidence. We assessed the clinical outcomes for children and adolescents treated for XDR-and pre-XDR-TB.

Extended Time-Dependent Density Functional Theory for Multibody Densities.

Time-dependent density functional theory (TDDFT) is widely used for understanding and predicting properties and behaviors of matter. As one of the fundamental theorems in TDDFT, Van Leeuwen theorem [Phys. Rev.