Publications by authors named "J C Lecron"
Background: Chronic rhinosinusitis with nasal polyp (CRSwNP) is a typical type 2 inflammation involving interleukin (IL)-4 and IL-13. Dupilumab is a fully human monoclonal antibody targeting IL-4 receptor α subunit, thereby blocking signaling by both cytokines. Our hypothesis was that IL-4 and IL-13, by inducing a severe epithelial dysregulation, are involved in CRSwNP pathogenesis.
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- A vaccine works best when it triggers the immune system to fight off germs. Different ingredients called adjuvants help boost this immune response.
- Scientists tested a new type of liposome (a tiny bubble) combined with special molecules to see how well it helps the immune system recognize a specific bacteria, Staphylococcus aureus.
- The results showed that this new mix could help create strong immune defenses in mice, making it a good candidate for future vaccines against tricky germs.
Article Synopsis
- The study investigates the link between sebaceous neoplasms (SNs) and Muir-Torre syndrome (MTS), aiming to find the best methods for early detection of associated internal cancers.
- It involves 107 patients and employs immunohistochemistry (IHC) and molecular biology techniques to assess the presence of deficient mismatch repair (dMMR) in these tumors, alongside calculating a Mayo Clinic risk score for MTS.
- Findings suggest that using the Mayo Clinic risk score as a first step, followed by IHC testing, offers the most effective and cost-efficient approach to screen for MTS in patients with SNs.