PAM50 breast cancer subtypes and survival of patients in rural Ethiopia without adjuvant treatment: a prospective observational study.

Purpose: Survival rates of breast cancer (BC) patients are particularly low in rural regions in sub-Saharan Africa (SSA) which is due to limited access to therapy. In recent years, gene expression profiling (GEP) of BC showed a strong prognostic value in patients with local tumour surgery and (neo)adjuvant treatment. The aim of this study was to evaluate the impact of intrinsic subtypes on survival of patients in rural Ethiopia without any (neo)adjuvant therapy.

Wild harbour porpoises startle and flee at low received levels from acoustic harassment device.

Acoustic Harassment Devices (AHD) are widely used to deter marine mammals from aquaculture depredation, and from pile driving operations that may otherwise cause hearing damage. However, little is known about the behavioural and physiological effects of these devices. Here, we investigate the physiological and behavioural responses of harbour porpoises (Phocoena phocoena) to a commercial AHD in Danish waters.

[Laryngeal traumas in children caused by trampoline accidents].

Laryngeal trauma is rare in children due to the anatomical placement and the trauma mechanisms required for injury. Recently the trampoline has become frequent in Danish households leading to more high-energy laryngeal traumas. This case report is about two incidents occurring within a year.

Fine-scale movement responses of free-ranging harbour porpoises to capture, tagging and short-term noise pulses from a single airgun.

Knowledge about the impact of anthropogenic disturbances on the behavioural responses of cetaceans is constrained by lack of data on fine-scale movements of individuals. We equipped five free-ranging harbour porpoises () with high-resolution location and dive loggers and exposed them to a single 10 inch underwater airgun producing high-intensity noise pulses (2-3 s intervals) for 1 min. All five porpoises responded to capture and tagging with longer, faster and more directed movements as well as with shorter, shallower, less wiggly dives immediately after release, with natural behaviour resumed in less than or equal to 24 h.

Perceptually optimized image rendering.

We develop a framework for rendering photographic images by directly optimizing their perceptual similarity to the original visual scene. Specifically, over the set of all images that can be rendered on a given display, we minimize the normalized Laplacian pyramid distance (NLPD), a measure of perceptual dissimilarity that is derived from a simple model of the early stages of the human visual system. When rendering images acquired with a higher dynamic range than that of the display, we find that the optimization boosts the contrast of low-contrast features without introducing significant artifacts, yielding results of comparable visual quality to current state-of-the-art methods, but without manual intervention or parameter adjustment.