SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.

Synaptic dysfunction is a primary hallmark of both Alzheimer's and Parkinson's disease, leading to cognitive and behavioral decline. While alpha-synuclein, beta-amyloid, and tau are involved in the physiological functioning of synapses, their pathological aggregation has been linked to synaptopathology. The methodology for studying the small-soluble protein aggregates formed by these proteins is limited.

The status of China's international division of labour from Marx's theory of international value.

Based on Marx's theory of international value, this paper analyzes the carrier of unequal exchange and the path of international transfer of surplus value, constructs an international division of labour status index by comprehensively observing the organic composition of capital in the export and import sectors, and tries to accurately grasp the characteristics of the current international division of labour pattern coexisting between horizontal products and vertical products. At the same time, based on the data of all available HS92 six-digit code categories in various countries in the world from 1993 to 2016, the level of international division of labour in China is empirically analysed. The results show that: (1) there is no breakthrough in the situation of China's low status of international division of labour; (2) the high capital-organic composition of the import sector is the main reason for the low status of international division of labour; (3) the continuous decline in the absolute value of captured surplus is a global phenomenon; (4) WTO accession has not significantly improved the status of international division of labour.

Immunobridging Trials: An Important Tool to Protect Vulnerable and Immunocompromised Patients Against Evolving Pathogens.

Safeguarding patients from emerging infectious diseases demands strategies that prioritise patient well-being and protection. Immunobridging is an established trial methodology which has been increasingly employed to ensure patient protection and provide clinicians with swift access to vaccines. It uses immunological markers to infer the effectiveness of a new drug through a surrogate measure of efficacy.

Outcomes of pediatric patients with suspected allergies to COVID-19 vaccines.

Background: Adverse effects following immunizations (AEFIs) can contribute to vaccine hesitancy.

Objective: We evaluated clinical outcomes of AEFIs subsequent to administration of the coronavirus disease 2019 (COVID-19) vaccine at 2 pediatric allergy centers.

Methods: Data on pediatric patients referred for COVID-19 AEFI concerns between March 2021 and October 2022 were reviewed.