Two-year radiologic assessment of the Pinnacle cup-a migration analysis with EBRA.

Introduction: The most common cause of failure in total hip arthroplasty (THA) is aseptic loosening. Uncemented cup migration analysis by EBRA (Einzel-Bild-Roentgen-Analyse) has shown to be a good predictive indicator for early implant failure if the cup migrates more than 1 milimeter (mm) within the first 2 years after surgery. In this study, we investigated the migration behaviour of an uncemented press-fit cup after 2 years follow-up.

[Trochleoplasty: Surgical technique : Video article].

A 29-year-old physically active patient presented with recurrent right-sided patellar dislocation. Clinical and radiological investigation showed patellar instability with stable cruciate and collateral ligaments, excess internal rotation of the right femur, as well as trochlear dysplasia. Treatment consisted of trochleoplasty in combination with medial patellofemoral ligament reconstruction.

"Inflamm-aging" influences immune cell survival factors in human bone marrow.

The bone marrow (BM) plays a key role in the long-term maintenance of immunological memory. However, the impact of aging on the production of survival factors for effector/memory T cells and plasma cells in the human BM has not been studied. We now show that the expression of molecules involved in the maintenance of immunological memory in the human BM changes with age.

Plasma cell numbers decrease in bone marrow of old patients.

The BM is well understood to play a key role in plasma cell homing and survival in mice. In humans, BM plasma cells and their functions are less well characterized. In this study, we used paired bone biopsies from the femur shaft and blood samples from persons of different ages to analyze age-related changes of plasma and memory B cells.

Bone marrow T cells from the femur are similar to iliac crest derived cells in old age and represent a useful tool for studying the aged immune system.

Background: CD4+ and CD8+ T cells reside in the human bone marrow (BM) and show a heightened activation state. However, only small sample sizes are available from sources such as the iliac crest. Larger samples can be obtained from the femur in the course of hip replacement surgery.