Publications by authors named "J C LaCaille"
Article Synopsis
- The study focused on high-grade epithelial ovarian cancer survivors post-chemotherapy, analyzing their sleep quality, duration, efficiency, and insomnia, and how these factors relate to the risk of disease recurrence.
- Out of 97 women surveyed, over half reported poor sleep quality, efficiency, and duration, while a majority did not experience insomnia; these sleep patterns remained consistent after four months.
- The results indicated no significant correlation between sleep characteristics and cancer recurrence overall, but suggested a potential association for fully platinum-sensitive women, highlighting the need for further research with larger groups to clarify these relationships.
Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli-a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks).
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- The TRIO gene has been linked to intellectual deficiency, autism spectrum disorder, and developmental epileptic encephalopathies due to recessive and de novo mutations.
- Research indicates that TRIO is essential for the migration of GABAergic interneurons, specifically regulating their movement during brain development through its guanine nucleotide exchange factor (GEF) domains.
- In studies involving Trio mutant mice, findings revealed reduced numbers of migrating interneurons, leading to increased seizures and behavioral issues, highlighting TRIO's crucial role in maintaining cortical inhibition and proper neuronal migration dynamics.
The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long-term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using targeted deletion of the activating transcription factor 4 (ATF4), a key downstream effector of the ISR, in various neuronal and non-neuronal cell types.
View Article and Find Full Text PDFThe ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.
Alzheimers Dement
August 2024
Introduction: Impaired brain protein synthesis, synaptic plasticity, and memory are major hallmarks of Alzheimer's disease (AD). The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) has been shown to modulate protein synthesis, but its effects on memory in AD models remain elusive.
Methods: We investigated the effects of HNK on hippocampal protein synthesis, long-term potentiation (LTP), and memory in AD mouse models.