Publications by authors named "J C Kath"
Article Synopsis
- Arbuscular mycorrhizal (AM) fungi are vital in ecosystems, helping plants thrive by reducing the need for chemical fertilizers and enhancing resilience to pests, yet their ecological roles are not fully understood, impacting predictions related to climate change and agricultural productivity.
- The competitor-stress-tolerator-ruderal (C-S-R) framework is used to classify AM fungi based on their functional traits, aiming to improve predictions about their responses to global changes, but its effectiveness is challenged by the fungi's obligate symbiotic nature and limited data availability.
- To improve the C-S-R framework's predictive ability, more comprehensive research on AM fungal traits is needed, advocating for better data collection and management, which
White-nose syndrome (WNS) is a fungal wildlife disease of bats that has caused precipitous declines in certain Nearctic bat species. A key driver of mortality is premature exhaustion of fat reserves, primarily white adipose tissue (WAT), that bats rely on to meet their metabolic needs during winter. However, the pathophysiological and metabolic effects of WNS have remained ill-defined.
View Article and Find Full Text PDFArticle Synopsis
- Plasma cells (PCs) in bone marrow are key players in immune responses, involved in both diseases like multiple myeloma and conditions such as autoimmune disorders.
- Current research on human PCs is limited due to challenges in traditional culture methods; hence, a new dynamic 3D bone marrow culture system (BM-MPS) has been developed to better mimic the natural environment of PCs.
- This innovative system, supported by a collagen-hyaluronic acid hydrogel, not only preserves the native bone marrow structure but also allows for long-term survival and functionality of primary-derived non-malignant PCs, paving the way for targeted therapeutic strategies.
Agroforestry is a management strategy for mitigating the negative impacts of climate and adapting to sustainable farming systems. The successful implementation of agroforestry strategies requires that climate risks are appropriately assessed. The spatial scale, a critical determinant influencing climate impact assessments and, subsequently, agroforestry strategies, has been an overlooked dimension in the literature.
View Article and Find Full Text PDFChimeric antigen receptor (CAR)-redirected immune cells hold significant therapeutic potential for oncology, autoimmune diseases, transplant medicine, and infections. All approved CAR-T therapies rely on personalized manufacturing using undirected viral gene transfer, which results in nonphysiological regulation of CAR-signaling and limits their accessibility due to logistical challenges, high costs and biosafety requirements. Random gene transfer modalities pose a risk of malignant transformation by insertional mutagenesis.
View Article and Find Full Text PDF