Uncovering NK cell sabotage in gut diseases via single cell transcriptomics.

The identification of immune environments and cellular interactions in the colon microenvironment is essential for understanding the mechanisms of chronic inflammatory disease. Despite occurring in the same organ, there is a significant gap in understanding the pathophysiology of ulcerative colitis (UC) and colorectal cancer (CRC). Our study aims to address the distinct immunopathological response of UC and CRC.

Clinical Manifestations.

Background: Endogenous estrogen history across the life course may be associated with better cognitive maintenance. Few large longitudinal studies have evaluated this prospectively, and results have been inconsistent. We assessed the association of reproductive span, an indicator of endogenous estrogen history, with cognitive change in older women.

Clinical Manifestations.

Background: In Alzheimer's disease research, subjective report of cognitive and functional decline from participant-study partner (SP) dyads is an efficient method of assessing cognitive impairment and risk of clinical progression. The extent to which discordance (disagreement) between self- and SP-report is associated with diagnosis of cognitive impairment is not known.

Method: We tested the hypothesis that discordance between baseline self- and SP-report Everyday Cognition Scale (ECog) scores was associated with greater probability of mild cognitive impairment (MCI) diagnosis.

Clinical Manifestations.

Background: The Everyday Cognition questionnaire is a sensitive tool for measuring decline in activities of daily living and can differentiate dementia from normal cognition. There is limited data on comparing the ECog-12 performance by raters (self vs. informant/study-partner) and scoring systems (continuous average score vs.