Publications by authors named "J C Jensenius"
Article Synopsis
- The study examines how in utero adversities like hypoxia and malnutrition relate to the development of schizophrenia (SZ) by investigating specific proteins (l-ficolin and MASP-2) linked to the immune response in patients.
- Results show that SZ patients had significantly higher levels of l-ficolin (about 40% increase) and a notable gender difference in MASP-2 levels, especially among female patients.
- The study also notes that while there are increases in certain protein activities in SZ, there was no significant association with demographic factors like age, family history, or smoking habits.
Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke.
Pharmgenomics Pers Med
October 2021
Article Synopsis
- * Researchers analyzed 122 IS patients and 150 controls using immunofluorometric assays and real-time PCR, finding significantly higher M-ficolin levels in IS patients and identifying several SNPs that negatively correlate with IS risk.
- * The findings suggest that changes in LCP PRMs may influence the risk and progression of ischemic stroke, highlighting the role of genetic and protein level alterations in the disease mechanisms, especially in the Armenian population studied.
Article Synopsis
- There are various methods for detecting complement activation products, but no universal standard exists for clinical measurement.
- The text outlines a modified assay for measuring C3dg, which is a component related to complement activation.
- This modified assay is highlighted as simple, inexpensive, and stable, providing an accurate reflection of complement turnover regardless of the activation pathway.
Article Synopsis
- The study investigates the role of natural antibodies, specifically anti-αGal, in defending against pneumococcal infections caused by Streptococcus pneumoniae.
- Researchers found that anti-αGal antibodies, despite not specifically targeting the known pneumococcal capsular types, can react with a significant number of pneumococcal serotypes and aid in microbial detection.
- Evidence shows that higher levels of anti-αGal are linked to lower rates of pneumococcal infections, suggesting that these antibodies play a crucial role in enhancing human immunity against a variety of pathogens.
Article Synopsis
- Researchers studied the levels of ficolins and mannose-binding lectin (MBL) in 157 patients with acute myeloid leukaemia (AML) compared to 267 healthy individuals.
- They found that ficolin-1 was significantly lower in AML patients, while ficolin-2, ficolin-3, and MBL were higher, with the highest MBL levels linked to a greater risk of severe infections.
- Genotyping suggested a specific genetic variant (G/G homozygosity) associated with the disease, and ficolins could serve as potential new biomarkers for diagnosing AML and distinguishing it from other blood cancers.