Publications by authors named "J C Jaume"
Article Synopsis
- Vitamin D testing and supplement usage have increased significantly, yet many patients still remain deficient in vitamin D (less than 30 ng/mL).
- A study analyzed data from 6,912 patients between 2014 and 2022, finding that while testing rates rose from 42.1% to 92.7%, only 25.5% achieved adequate vitamin D levels by 2022.
- Current users of high-dose supplements for over 12 months showed the best results, but overall, only a minority of patients reached sufficient vitamin D levels despite increased testing and usage.
Article Synopsis
- Chronic lymphocytic thyroiditis (Hashimoto thyroiditis) has been thought to increase the risk of differentiated thyroid cancer (DTC), but this study aims to challenge that idea by examining the relationship between thyroid peroxidase antibodies (TPO-Abs) and DTC.
- The research involved collecting data from 8,461 thyroid surgeries over several years at different clinical sites in the USA and Greece, analyzing TPO-Abs levels in 1,635 patients, with a focus on those with DTC and benign cases.
- Results showed that higher TPO-Ab levels were associated with a lower incidence of DTC, indicating a protective effect, as the frequency of DTC decreased as TPO-Ab titers increased in a
Background: Thyroid nodules are an extremely common entity, and surgery is considered the ultimate diagnostic strategy in those with unclear malignant potential. Unfortunately, strategies aiming to predict the risk of malignancy have inadequate specificity. Our group recently found that the microenvironment of thyroid cancer is characterized by an enhanced immune invasion and activated immune response mediated by double-negative T lymphocytes (DN T) (CD3CD4CD8), which are believed to enable or promote tumorigenesis.
View Article and Find Full Text PDFHyperinsulinemia promotes fat accumulation, causing obesity. Being an inflammatory state, obesity can induce further inflammation and is a risk factor for HPA (hypothalamic pituitary axis) dysregulation through hypercortisolism-related hyperglycemia. In another hypothesis, the sympathetic nervous system (SNS) plays a significant role in the regulation of hormone secretion from the pancreas such as an increase in catecholamines and glucagon as well as a decrease in plasma insulin levels, a disruption on SNS activity increases insulin levels, and induces glycogenolysis in the liver and lipolysis in adipose tissue during hypoglycemia.
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