Publications by authors named "J C J Bot"
This retrospective multicenter study examines therapy-induced orbital and ocular MRI findings in retinoblastoma patients following selective intra-arterial chemotherapy (SIAC) and quantifies the impact of SIAC on ocular and optic nerve growth. Patients were selected based on medical chart review, with inclusion criteria requiring the availability of posttreatment MR imaging encompassing T2-weighted and T1-weighted images (pre- and post-intravenous gadolinium administration). Qualitative features and quantitative measurements were independently scored by experienced radiologists, with deep learning segmentation aiding total eye volume assessment.
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- The purpose of the study was to look at how different treatments for lymphatic malformations (LMs) in the head and neck work, to help decide what treatment is best.
- The researchers reviewed a lot of articles and found that out of over 9,000, only 54 studies were useful, involving 1,573 young patients.
- They learned that while different treatments didn’t show a big difference in reducing the size of the malformations, surgery and treating bigger cysts were better at reducing their size compared to other treatments.
Article Synopsis
- In the Netherlands, a strong collaboration in drug regulatory science has emerged, influenced by key stakeholders in research, policy, and regulation.
- The review highlights three main episodes: the TI Pharma Escher-project, the Dutch Medicines Evaluation Board's impact, and the establishment of the Regulatory Science Network Netherlands, which fostered multistakeholder engagement.
- Factors like evolving European legal frameworks and the contributions of clinical pharmacology have shaped regulatory science, emphasizing the importance of robust clinical evidence for drug approval and enhancing connections among various parties involved.
Risk assessment of vascular complications following manual therapy and exercise for the cervical region: diagnostic accuracy of the International Federation of Orthopaedic Manipulative Physical Therapists framework (The Go4Safe project).
J Physiother
October 2023
Question: What is the diagnostic accuracy of the International Federation of Orthopaedic Manipulative Physical Therapists (IFOMPT) framework to assess the risk of vascular complications in patients seeking physiotherapy care for neck pain and/or headache?
Design: Cross-sectional diagnostic accuracy study.
Participants: One hundred and fifty patients seeking physiotherapy for neck pain and/or headache in primary care.
Methods: Nineteen physiotherapists performed the index test according to the IFOMPT framework.
In sialendoscopy, ducts are dilated and the salivary glands are irrigated with saline. Contrast-enhanced ultrasound sialendoscopy (CEUSS), using microbubbles, may facilitate the monitoring of irrigation solution penetration in the ductal system and parenchyma. It is imperative to test CEUSS for its safety and feasibility in Sjögren's syndrome (SS) patients.
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