Publications by authors named "J C Izpisua Belmonte"
The dataset presents a 43 year-long reanalysis of pollen seasons for three major allergenic genera of trees in Europe: alder (Alnus), birch (Betula), and olive (Olea). Driven by the meteorological reanalysis ERA5, the atmospheric composition model SILAM predicted the flowering period and calculated the Europe-wide dispersion pattern of pollen for the years 1980-2022. The model applied an extended 4-dimensional variational data assimilation of in-situ observations of aerobiological networks in 34 European countries to reproduce the inter-annual variability and trends of pollen production and distribution.
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- Soft tissue sarcomas typically don’t have links to mutations in the MEN1 gene.
- A case is presented involving a patient with a sizeable retroperitoneal pleomorphic liposarcoma that has a unique MEN1 mutation not previously documented in relation to soft tissue sarcomas.
- This finding broadens the understanding of cancers related to MEN1 mutations.
Article Synopsis
- Researchers used a single dose of adeno-associated viruses (AAVs) targeting specific genes to partially reprogram aged and stressed cells in mice with Hutchinson-Gilford progeria syndrome (HGPS), leading to reduced inflammation and prolonged life spans.
- This targeted reprogramming also improved bone marrow and spleen function, delayed aging symptoms in natural wild-type mice, and enhanced wound healing, suggesting potential benefits for health and longevity in the elderly.
Dysfunction of the ribosome manifests during cellular senescence and contributes to tissue aging, functional decline, and development of aging-related disorders in ways that have remained enigmatic. Here, we conducted a comprehensive CRISPR-based loss-of-function (LOF) screen of ribosome-associated genes (RAGs) in human mesenchymal progenitor cells (hMPCs). Through this approach, we identified ribosomal protein L22 (RPL22) as the foremost RAG whose deficiency mitigates the effects of cellular senescence.
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