Publications by authors named "J C Howe"
As the global quest for sustainable energy keeps rising, exploring novel efficient and practical photocatalysts remains a research and industrial urge. Particularly, metal organic frameworks were proven to contribute to various stages of the carbon cycle, from CO capture to its conversion. Herein, we report the photo-methanation activity of three isostructural, nickel-based metal organic frameworks incorporating additional niobium, iron, and aluminum sites, having demonstrated exceptional CO capture abilities from thin air in previous reports.
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- Benzene degradation under anoxic conditions has been studied for over 25 years, but the activation mechanism remains unclear due to challenges in cultivating anaerobic benzene-degrading cultures.
- Our lab has maintained a slow-growing methanogenic enrichment culture named ORM2, which is a unique benzene fermenter related to other known degraders, but it has a long doubling time and lag phase.
- We created a FISH probe to visualize ORM2 cells, discovering they cluster with methanogens and may produce substances that promote aggregation; higher benzene concentrations seem to hinder this aggregation, shedding light on the community dynamics to improve ORM2's growth rate.
Autism spectrum disorder (ASD) displays a notable male bias in prevalence. Research into rare (<0.1) genetic variants on the X chromosome has implicated over 20 genes in ASD pathogenesis, such as MECP2, DDX3X, and DMD.
View Article and Find Full Text PDFAutism spectrum disorder (ASD) exhibits an ∼4:1 male-to-female sex bias and is characterized by early-onset impairment of social/communication skills, restricted interests, and stereotyped behaviors. Disruption of the Xp22.11 locus has been associated with ASD in males.
View Article and Find Full Text PDFIntroduction: Myeloid neoplasms (MNs) frequently harbor pathogenic mutations not detected by karyotyping and fluorescence in situ hybridization; hence, next-generation sequencing (NGS) is necessary for diagnosis, risk stratification, and therapy. If, however, NGS is not clinically indicated but still performed, the results may promote futile avenues of investigation, heighten patient distress, and increase cost.
Methods: We created criteria to approve NGS testing for MN (MN-NGS) with the goal of maximizing actionable results.