Contrary to Pemetrexed-containing chemo-immunotherapy studies, Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel (ABCP) treatment has consistently shown clinical benefit in prospective studies in patients with lung cancer and actionable mutations, where intracranial metastases are common. Here, we aimed to describe the real-life population of patients fit to receive ABCP after targeted therapy and quantify its clinical effect in patients with brain metastases. Patients treated in Cheshire and Merseyside between 2019 and 2022 were identified.
View Article and Find Full Text PDFBackground: Tivozanib is a licensed as first-line treatment for metastatic renal cell carcinoma (mRCC).
Objective: To evaluate the outcomes from tivozanib in a real-world mRCC population.
Patients And Methods: Patients with mRCC commencing first-line tivozanib between March 2017 and May 2019 were identified across four specialist cancer centres in the UK.
Background: Withholding food is often recommended before collection of blood for routine biochemical analysis in dogs despite a paucity of evidence to support this requirement.
Objectives: To compare measurements of selected biochemical analytes collected before and after feeding in clinically healthy dogs.
Animals: One hundred clinically healthy staff- and student-owned dogs weighing ≥15 kg.
J Small Anim Pract
February 2023
Objectives: To describe how veterinarians utilise and perform urinalyses for dogs and cats.
Materials And Methods: A survey, developed and distributed through the Veterinary Information Network, enlisted veterinarians who perform urinalyses for dogs and cats. Participants were directed to question banks based on whether urinalyses were performed in-house, by an outside diagnostic laboratory, or using an in-house automated instrument.
Background: The IDEXX SediVue Dx (SediVue) is an automated, in-clinic urine sediment analyzer for veterinary patients. The bias between the results from manual microscopy and the SediVue is currently unknown.
Objectives: To assess the diagnostic accuracy of the SediVue, we aimed to determine the bias between the SediVue (index test) and manual microscopy (reference standard) for the quantification of RBCs and WBCs in urine.